OxyContin 80 mg Oxycodone release from OxyContin Tablets pH independent.
Oxycodone well absorbed from Oxy Tablets with an oral bioavailability of 60% to 87%.
The relative oral bioavailability of Oxy to immediate-release oral dosage forms is 100%.
so upon repeated dosing in normal volunteers in pharmacokinetic studies, steady-state levels were achieved within 24-36 hours.
Dose proportionality and/or bioavailability established for the 10 mg, 20 mg, 40 mg, 80 mg, and also 160 mg tablet strengths for both peak
plasma levels (Cmax) and extent of absorption (AUC).
Oxycodone extensively metabolized and also eliminated primarily in the urine as both conjugated and unconjugated metabolites.
The apparent elimination half-life of oxycodone following the administration of OxyContin 4.5 hours compared to 3.2 hours for immediate-release oxycodone.
Use Oxy the way your doctor tells you to. not for occasional (“as needed”) use. • Swallow the tablets whole. Do not break, crush, dissolve, or chew them before swallowing. Oxy works properly over 12 hours only when swallowed whole.